Kacip Fatimah Extract (Labisia Pumila Extract)

Labisia pumila (Myrsinaceae) is known as Kacip Fatimah in Malaysia and is traditionally used by Malay women. It can be widely found throughout the rain forest of Indochina, particularly in Malaysia. There are three varieties of L. pumila in Malaysia which are var. pumila, var. alata and var. lanceolata. These varieties can be differentiated from each other by their petiole and leaf characteristics. However, var. alata is more frequently used in traditional medicine preparations.

The plants are usually boiled and the water-soluble extract is taken as a drink. A decoction of the herb (the whole plant) is administered 1 to 2 months before childbirth to help strengthen and tone abdominal muscles and the vaginal wall and tissue. In daily practice, it is used for the general well-being and vitality of women, maintaining the figure and appearance, aiding in reducing symptoms related to hormonal imbalance, and increasing libido in women. Its exclusive use by women has led to the belief that it exhibits (phyto)-estrogenic activity, contains compounds with similar chemical structures to estrogens and therefore is able to relieve menopausal symptoms.

Pure Kacip Fatimah Labisia pumila Extract must have Gallic Acid!

Without Gallic Acid, its not Kacip Fatimah Labisia Pumila!
0.3-0.8% Gallic Acid (Bioactive Phytochemicals)

Vegan
Non-GMO
No Fillers
No Flavors
No Additives
No Preservatives
No Artificial Colors
Soy and Gluten Free
Lab Tested for Authentic & Active Compound
Origin from Malaysia Borneo Forest

Health Benefits

Improve female reproductive system
Improve well-being and vitality
Improve blood circulations and regulate pressure
Increase energy and overcomes fatigue
May relieve the symptoms of menopause
Powerful libido and energy booster

	BIONUTRICIA Kacip Fatimah Extract	BRAND X
Certification	Registered with the Ministry of Health, Halal Tested	Not registered & certified
Raw Ingredients	Kacip Fatimah from Malaysia	Very little / no raw ingredients; Use non-Kacip Fatimah materials
Process	Extracted through R.O. water & Ultra-sonic; Full bio-active ingredients	Grinded root powder; Extracted through ethanol process
Active Compound	Tested with high amount of Gallic Acid	Not Tested
Formulation	Only Kacip Fatimah – which is proven safe and effective	Combination of other ingredients (effectiveness & safety is not proven); Added with prohibited drugs
Label	Transparent, standardized KF extract with 0.3-0.8% Gallic Acid	Misleading claim (quantity), incorrect amount of Kacip Fatimah extract, mostly filler ingredients

High Standard Product Quality Control

Our Standardized Kacip Fatimah extracts are tested by Sirim which contain high amount of active compounds

Skin Beauty

In vitro study on effect of Kacip Fatimah extract on skin
Subject	Adult humans (n = 10) Fasting blood glucose ≤ 66.2 mmol/l, BMI = 20–25 kg/m2, age 27–55 years, non-smokers, no physical defect
Duration of the study	24, 48, 72 hr
Dosage	Water extract: 0.001˗0.01%
Groups	Control +UV Ascorbic acid treated Kacip Fatimah (KF) extract treated
Parameters analysed	Antioxidant assay Pro-inflammaotry cytokine (TNF-α) content Expression of collagen degrading proteolytic enzyme (MMP-1, MMP-9) COX-2 and type 1 pro-collagen levels
Function The KF water extract has strong anti-antioxidant activity and it protects dermal fibroblasts from cell death induced by UVB. KF extract has tremendous potential as an anti-photoaging cosmetic ingredient.	Visible benefits The 50% free radical scavenging activity of KF extract was 0.006% = 156 μM ascorbic acid. Treatment with KF extract markedly inhibited the TNF-α production and the expression of COX-2 stimulated by UV irradiation. Decreased collagen synthesis of human fibroblasts by UVB was restored back to normal level after treatment with KF extract. The enhanced MMP-1 and MMP-9 expression upon UVB irradiation was down regulated by KF extract.

Bone Health

In vivo studies on effect of Kacip Fatimah extract on osteoporosis
Subject	Female rats (n=96)	Female rats (n=32)
Duration of the study	9 weeks	2 months
Dosage	20mg/kg and 100 mg/kg	17.5 mg/kg daily orally
Groups	Baseline group (BL) Sham-operated (Sham) Ovariectomised control (OVXC) Ovariectomised (OVX) + 64.5 μg/kg Ovariectomised + 20 mg/kg LP (LP20) Ovariectomised + 100 mg/kg LP (LP100)	Sham OVXC ERT LP
Parameters analysed	Bone oxidative enzyme levels Malondialdehyde (MDA): product of lipid peroxidation Glutathione peroxidase (GPx) and superoxide dismutase (SOD): parameters of antioxidant defense system	Bone histomorphometry
Function LP supplementation at long term may reduce oxidative stress which in turn may prevent bone loss via its anti-oxidative property. LP has potential as an alternative to ERT for prevention of postmenopausal osteoporosis.	Visible benefits The SOD and GPx levels of the LP treatment group were higher than the OVX groups. Both LP20 and LP100 groups at the 9th week of treatment had lower MDA levels than the ERT group.	Visible benefits Histomorphometric analysis revealed osteoporotic changes for the ovariectomized rats.

Weight Loss

In vivo study on effect of Kacip Fatimah extract on body weight
Subject	Adult rats
Duration of the study	30 days
Dosage	10, 20, 50 mg/kg/day LP water extract
Groups	Sham-operated (Sham) OVX+ERT (0.625 mg/kg/day) OVX+10 mg/kg/day (LP10) OVX+20 mg/kg/day (LP20) OVX+50 mg/kg/day (LP50)
Parameters analysed	Plasma adipokines mRNA expressions of the adipokines in the adipose tissues
Function LP exerts uterotrophic effect and regulates body weight gain by modulating secretion of leptin and resistin, and expression of the adipokines in adipose tissues.	Visible benefits ERT and LP50 rats showed less weight gain than untreated OVX rats. Ovariectomy caused plasma leptin levels to decrease, but LP increased plasma leptin and mRNA expression of leptin to levels higher or comparable to Sham group. The elevated plasma resistin concentrations in OVX rats were reduced in rats given ERT and LP extracts. The uterus to body weight ratio increased upon treatment with LP.

Heart Health

In vivo studies on effect of Kacip Fatimah extract on cardiovascular disorder
Subject	Adult female rats (n=35)	Male rats (n=36) divided to normal and C11H17NO3-induced myocardial infarction individual
Duration of the study	4 months	28 days
Dosage	Water extract: 17.5mg/kg/day	Water extract: 100, 200, 400 mg/kg orally
Groups	Normal (NOR) Ovariectomized (OVXC) OVX+KF OVX+ERT (120 µg/kg/day)	Group I: normal-control group Group II: ISO-control group Group III: C16H21NO2+ISO Group IV: 100 mg/kg LP+ISO Group V: 200 mg/kg LP+ISO Group VI: 400 mg/kg LP+ISO
Parameters analysed	Histological analysis of aorta	Cardiac marker enzyme analysis Antioxidant system analysis Histology analysis
Function LP modulates postmenopausal cardiovascular risks acting similar to estrogen. The cardioprotective effects of LP was due to its capability to augment the myocardial antioxidant enzyme levels and enhance the permeability and integrity of the myocardial cell membrane.	Visible benefits LP treatment maintained the elastic lamellae architecture of the ovariectomized rat aortae in a manner comparable to normal rats. LP acts as phytoestrogens to interact with the estrogen receptor and exert estrogen-like effects.	Visible benefits LP pretreated rats showed a dose-dependent decrease in cardiac enzyme activities (cTnI, CK-MB, LDH, ALT and AST) when compared with ISO-control rats. LP pretreated rats had rises in the activity of oxidase enzymes (GPx, CAT and SOD) when compared with ISO-control group. Pre-treated rats has an improvement in membrane cell integrity compared to untreated rats.

Effects of aqueous extract of L. pumila var. alata on cardiac marker enzymes and antioxidant system in rats.

Data is presented as mean ± SD (n = 6). a Significantly different to C11H17NO3-induced (negative control) group at p < 0.05; b Significantly different to normal group at p < 0.05; c Significantly different to C16H21NO2(positive control) group at p < 0.05. Activity is expressed as U/L for serum LDH and AST; IU/L for serum ALT; U/mL for serum SOD, CAT and GPx; U/mg protein for myocardium SOD, CAT and GPx. LDH = Lactate dehydrogenase; AST = Aspartate transaminase; ALT = Alanine transaminase; SOD = Superoxide dismutase; CAT = Catalase; GPx = Glutathione peroxidase.

Effect of the aqueous extracts of Labisia pumila var. alata on histopathological changes, (A) control (normal), (B) ISO (negative control), (C) C16H21NO2 10 mg/kg (positive control), (D): LP 100 mg/kg, (E) LP 200 mg/kg, (F) LP 400 mg/kg. Heart tissues (4 µm thickness) were stained with hematoxylin and eosin and visualized under light microscope at ×10 magnification.

Maintain A Healthy Female Reproductive System

In vivo study on effect of Kacip Fatimah extract on vagina
Subject	Ovariectomized adult female rats (n=36)
Duration of the study	7 days
Dosage	100μg/ml, 250μg/ml and 500μg/ml
Groups	Ovariectomized + no intravaginal gel (NG) OVX+ERT (0.625 mg/kg/day) Ovariectomized + intravaginal plain gel (PG) Ovariectomized + intravaginal LP 100 gel Ovariectomized + intravaginal LP 250 gel Ovariectomized + intravaginal LP 500 gel Ovariectomized + intravaginal 0.005% estriol gel (E)
Parameters analysed	Histological analysis Protein expression
Function Intravaginal LP was able to ameliorate features associated with vaginal atrophy (happened in post-menopause) via inducing the increase in the vaginal epithelial cell proliferation, improving the vaginal lubrication, and restoring the vaginal fluid acidity.	Visible benefits Thickness of vaginal epithelium increased with increasing intravaginal LP doses. LP increased expression and distribution of proliferative protein (PCNA), tight junction protein (occludin), water channel proteins (AQP-1 and AQP-2) and proton extruder protein (V-ATPase A1) in the vagina. LP induced desmosome formation and approximation of the intercellular spaces between the vaginal epithelium.

Quantitative measurement of vaginal epithelial thickness.
Groups (n = 6)	Epithelial thickness (μm)
NG	10.45 ± 2.62
PG	10.63 ± 1.21
LP100	31.84 ± 5.85*
LP250	46.38 ± 3.78*
LP500	72.49 ± 16.16*
E	97.85 ± 7.35*

Values represent means ± S.E.M for 6 rats per group. *p<0.05 compared to sham and control.

Standardized Malaysia Pure 100:1 Kacip Fatimah Powder Extract 0.3-0.8% Gallic Acid

Pure 100:1 Kacip Fatima Labisia pumila Extract
0.3-0.8% Gallic Acid (Bio-active Phytonutrient)
Ultrasonic hot water extraction
Scientifically tested
Improve female reproductive system
Improve well-being and vitality
Improve blood circulations and regulate pressure
Increase energy and overcomes fatigue
May relieve the symptoms of menopause
Powerful libido and energy booster

Knowledge: Kacip Fatimah (Labisia pumila)