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Knowledge: Senna Leaf (Senna Alexandrina)

Senna Leaf (Senna Alexandrina)

Senna leaf Senna alexandrina is an ayurvedic herb more popularly known as senna. Senna is among the most well-known and frequently used laxative ingredients in teas. Senna tea is made from the dried leaves and pods of the Senna alexandrina shrub.The senna plant contains compounds called glycosides, known as Sennosides A & B that stimulate the digestive system. It is an FDA approved nonprescription laxative. Due to its laxative property it is used to clear bowel before diagnostic tests such as colonoscopy.

The genus senna comprising of 500 species of which 26 species of genus cassia have been reported to contain anthracene derivatives either in the free form or glycosides. Out of these, Cassia angustifolia (Indian senna) and Cassia acutifolia (Alexandrian senna) are official in different pharmacopoeias, because of laxative activity and also because they are available in large quantities.

The maximum daily dose to treat constipation is 15 to 30 mg sennosides. However the correct individual dose is the smallest required producing a comfortable soft-formed motion. The dosage for senna is about 500 mg to 2 gm of the powder of leaf or pod.

Pure Senna Leaf Senna Alexandrina Extract must have Sennosides!

Without Sennosides, it’s not Senna Leaf Senna alexandrina! (>10%) Sennosides (Bioactive Phytochemicals)
No harm/chemicals/preservative, just harmony, manufactured naturally

  • Vegan
  • Non-GMO
  • No Fillers
  • No Flavors
  • No Additives
  • No Preservatives
  • No Artificial Colors
  • Soy and Gluten Free
  • Lab Tested for Authentic & Active Compound
  • Origin from Malaysia Farm
 
 BIONUTRICIA Senna alexandrina Senna Leaf ExtractBRAND X
CertificationRegistered with the Ministry of Health, Halal TestedNot registered & certified
Raw IngredientsSenna alexandrina Senna Leaf Extract from MalaysiaVery little / no raw ingredients; Use non-Senna Leaf materials
ProcessExtracted through R.O. water & Ultra-sonic; Full bio-active ingredientsGrinded plant powder; Extracted through ethanol process
Active CompoundTested with high amount of SennosidesNot Tested
FormulationOnly Senna alexandrina Senna Leaf- which is proven safe and effectiveCombination of other ingredients (effectiveness & safety is not proven); Added with prohibited drugs
LabelTransparent, standardized Senna alexandrina Senna Leaf Extract (>10%) Sennosides (Bioactive Phytochemicals)Misleading claim (quantity), incorrect amount of Senna Leaf extract, mostly filler ingredients
 

Senna is an anthranoid type stimulating laxative. The laxative effect is due to the action of sennosides and their active metabolite, rhein-anthrone, in the colon. There are two different mechanism of action: 1. An influence on the motility of the large intestine: By the inhibition of water and electrolyte absorption from the large intestine, which increases the volume and pressure of the intestinal contents, resulting in propulsive contractions. 2. An influence on secretion processes: Stimulation of active chloride secretion increases water and electrolyte content of the intestine.

HALAL Certificate & High Standard Product Quality Control

Relieve Constipation

In vivo study on effect of senna extract on chemotherapy-induced constipation
Subject2 weeks
Duration of the study6 weeks
Dosage40mg/kg
Groups
  1. Crude fiber
  2. Senna extract
Parameters analysedAbdominal pain and stool properties
Function
Senna extract 40 mg/kg was effective and safe in treating chemotherapy-induced constipation.

Visible benefits

  • The effective rate of constipation by taking senna extract was 92.68% and that by the crude fiber diet was 10.93%.
  • The occurrence rate of abdominal pain after taking senna was 8.54% and the rate of loose stool was 35.53%.
 

Relieve Chronic Constipation

In vivo study on effect of senna powder on chronic constipation
SubjectParticipants with chronic constipation (n=48)
Duration of the study4 weeks
Dosage<1g senna powder per day
Groups
  1. Placebo
  2. Treatment
Parameters analysedQuestionnaire on severity of constipation and defecation difficulties
Function
Senna can be used to treat individuals with chronic functional constipation.

Visible benefits

  • Defecation frequency increased by 2.7 times in treatment group but only 1.3 times in placebo.
  • Defecation difficulties have been improved in treatment group.
 

Toxic

In vivo study on effect of senna extract on toxicity
SubjectRats (n=28)
Duration of the study4 weeks
DosageSenna extract 100mg/kg
Groups
  1. Control
  2. SAE (100 mg/kg)
  3. CdCl2 (0.6 mg/kg)
  4. SAE + CdCl2
Parameters analysedLiver function marker, oxidative stress marker and antioxidant enzyme activity in serum and liver
Function
SAE can be used as a promising protective agent against hepatotoxicity.

Visible benefits

  • SAE administration before CdCl2 exposure decreased cadmium deposition in liver tissue and the blood liver function indicators.
  • SAE pre-treatment prevented oxidative, inflammatory, and apoptotic reactions and decreased histological alterations to the liver caused by CdCl2 exposure.
 

Effect of senna extract on antioxidant enzyme activity

Standardized Pure Senna Alexandrina Senna Leaf Extract

  • Pure 100:1 Senna alexandrina Senna Leaf Extract
  • (>10%) Sennosides (Bioactive Phytochemicals)
  • Relieve constipation
  • Promote intestinal health
  • Natural colon cleanser
  • Improve digestive function
  • Help manage weight
  • Ultrasonic hot water extraction
  • Scientifically tested
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