Manjakani + Kacip Fatimah Herbosomal® Liposomal Delivery Differentiation Guide

Direct answer: A Herbosomal® liposomal Manjakani + Kacip Fatimah formulation encases each standardised extract inside phospholipid vesicles using Bionutricia’s proprietary encapsulation and sustained-release technology (registered trademark; patent-pending PI2023005773), differentiating it from a standard powder or liquid extract by adding particle-size verification, NanoVerify validation and a different set of CoA specifications a brand owner must set.

The combination of Manjakani (Quercus infectoria oak gall) and Kacip Fatimah (Labisia pumila) is one of the most established pairings in Malaysian traditional botanical formulations. Both ingredients carry deep heritage use in Southeast Asian women’s wellness, and both are standardised extracts that Bionutricia manufactures at its Sungai Buloh facility under JAKIM halal certification. For a brand owner evaluating whether to commission a standard extract formulation or a Herbosomal® liposomal version, the decision rests on specification, format, verification and commercial positioning — not on the ingredient alone.

This guide sets out what differentiates the two approaches from an OEM manufacturing perspective: what changes in the formulation structure, what additional specifications a CoA must carry, which formats each version suits, and what a brand owner should verify before requesting a quotation.

The Two Ingredients — Composition and Standardisation

Manjakani (Quercus infectoria) is an oak gall extract standardised to tannic acid 65–70% on a 100:1 extraction ratio. The extract is a brown, free-flowing, fully water-soluble powder with moisture below 8% and particle size >85% through 60 mesh. Heavy-metal limits on the specification are arsenic ≤0.5 ppm, lead ≤0.5 ppm, cadmium ≤0.3 ppm and mercury ≤0.05 ppm. Microbial limits are aerobic plate count ≤10⁴, yeast and mould ≤10³, coliforms ≤10², and E. coli absent. Shelf life is 24 months at <25 °C and RH <65%.

Kacip Fatimah (Labisia pumila) is a whole-plant extract standardised to gallic acid 0.3–0.8% on a 100:1 extraction ratio. The extract is a brown, free-flowing, fully water-soluble powder with moisture 2–8% and particle size >85% through 60 mesh. Named flavonoid actives include kaempferol, naringin and rutin. Heavy-metal limits are arsenic ≤0.1 ppm, lead ≤0.2 ppm and mercury ≤0.05 ppm. Microbial limits match the manjakani specification. Shelf life is 24 months at <25 °C and RH <65%.

Both ingredients are on Bionutricia’s JAKIM halal certificates, and both are processed using the patented enzymatic ultrasonic extraction (MY-188945-A) — a green-biotechnology process that produces standardised fractions meeting international quality and safety norms. A detailed internal specification and certificate of analysis are confirmed on file for each ingredient, and a brand owner should request the current specification before commissioning a formulation.

What Herbosomal® Liposomal Encapsulation Is

Herbosomal® — Bionutricia’s proprietary liposomal encapsulation and sustained-release technology (registered trademark; patent-pending PI2023005773) — pairs phyto-actives with phospholipid carriers to form microscopic vesicles around the extract compounds. In a standard formulation, the extract powder is simply dissolved or suspended in a liquid or filled into a sachet. In a Herbosomal® formulation, the extract is encased inside a phospholipid bilayer structure that becomes part of the finished product’s physical form.

The practical consequence for a brand owner is that a Herbosomal® product carries additional layers of verification that a standard extract does not. Particle size is confirmed through dynamic light scattering (DLS) rather than mesh screening, and the process is validated under NanoVerify — Malaysia’s nanotechnology verification programme. These are manufacturing and quality-control facts about how the product is made and verified, not claims about what the product does in the body.

Bionutricia already manufactures a Herbosomal® product containing both Kacip Fatimah and Manjakani extracts alongside other botanicals in its existing product range, which means the combination and the encapsulation technology are both proven in production at the Sungai Buloh facility.

Standard Extract vs Herbosomal® Format — Comparison

What the Research Shows

The published literature on both Quercus infectoria and Labisia pumila consists largely of phytochemical reviews and laboratory studies examining the composition and properties of these botanicals. For a brand owner commissioning an OEM formulation, the standardisation markers — tannic acid 65–70% for manjakani, gallic acid 0.3–0.8% for kacip fatimah — remain the primary quality anchors, regardless of whether the formulation uses a standard or Herbosomal® format. A CoA that confirms these markers, heavy-metal limits and microbial limits is the document a buyer should evaluate first.

Specification and CoA Requirements for Each Format

For a standard extract formulation, the CoA should confirm the active assay (tannic acid and gallic acid percentages), heavy metals within the limits stated above, microbial counts within specification, moisture content, and particle size through mesh screening. The extract powder is typically filled into powder sachets, mixed into pouch beverages, or filled into liquid bottles after dissolution.

For a Herbosomal® liposomal formulation, the CoA carries all of the above plus additional parameters specific to the encapsulation process. These include DLS particle-size data confirming the vesicle distribution is in the nanometre range, encapsulation efficiency confirming the percentage of active material incorporated into the phospholipid vesicles, and NanoVerify validation confirming the nanotechnology process. The phospholipid carrier itself — typically sunflower lecithin — is specified as part of the formulation. The finished product is typically filled into liquid sachets, gel sachets or liquid bottles, as the liposomal structure requires a liquid or gel phase to maintain vesicle integrity.

A brand owner should request the full finished-product specification, not just the raw-ingredient CoA, when evaluating a Herbosomal® formulation. The raw-ingredient CoA confirms what went in; the finished-product CoA confirms what came out.

Halal Chain and Certification

Both Manjakani and Kacip Fatimah extracts appear on Bionutricia’s JAKIM halal certificates, and the Herbosomal® manufacturing process operates within the same halal-certified facility in Sungai Buloh. For a brand owner targeting halal markets — domestically in Malaysia or for export to the GCC, ASEAN or other halal-conscious regions — the certification chain should be verified at three levels: the raw-ingredient halal certificate, the manufacturing facility’s JAKIM certification, and the finished-product halal status.

Beyond JAKIM halal, Bionutricia holds FSSC 22000, GMP, HACCP, US FDA registration and MeSTI certification, plus NanoVerify for the liposomal process. A brand owner should request the current certificate set as part of the supplier evaluation, and confirm that the specific formulation being commissioned is covered by the facility’s certification scope.

Manufacturing a Manjakani + Kacip Fatimah Product Under Your Own Brand

Bionutricia offers OEM and ODM manufacturing for brand owners and distributors commissioning a Manjakani + Kacip Fatimah supplement in either a standard or Herbosomal® format. The approved formats for this combination include powder sachets, liquid sachets, gel sachets, pouch beverages, chewable tablets and liquid bottles. The standard extract route suits powder sachets, pouch beverages and liquid bottles. The Herbosomal® route suits liquid sachets, gel sachets and liquid bottles, where the phospholipid vesicle structure is maintained in a liquid or gel phase.

The patented enzymatic ultrasonic extraction (MY-188945-A) is used for the botanical fraction, and Herbosomal® — Bionutricia’s proprietary liposomal encapsulation and sustained-release technology (registered trademark; patent-pending PI2023005773) — is available for the encapsulated format. The in-house authority team — a registered pharmacist, a nutritionist, a dietitian and a PhD biomedical scientist — supports formulation development from specification through to finished-product CoA.

The full certification set — JAKIM halal, FSSC 22000, GMP, HACCP, US FDA, MeSTI and NanoVerify — applies to the manufacturing process. A brand owner can request a quotation for either format, and the specification, CoA and halal documentation will be provided as part of the OEM dossier. For more detail on the liposomal manufacturing process, see Liposomal Supplement OEM: What Brand Owners Should Know Before Choosing a Manufacturer.

To request a quotation for a Manjakani + Kacip Fatimah formulation — standard or Herbosomal® — email ng@bio-nutricia.com or submit an enquiry through our website. The integrated manufacturing facility is located in Sungai Buloh, Selangor, Malaysia.

Frequently Asked Questions

What is the difference between a standard Manjakani + Kacip Fatimah extract and a Herbosomal® version?

A standard formulation uses the extract powder dissolved or suspended directly in a liquid or filled into a powder sachet. A Herbosomal® version encases the extract inside phospholipid vesicles using Bionutricia’s proprietary liposomal encapsulation and sustained-release technology (registered trademark; patent-pending PI2023005773), which adds DLS particle-size verification, NanoVerify validation and a phospholipid carrier specification to the CoA.

How is Herbosomal® liposomal encapsulation verified?

Herbosomal® encapsulation is verified through dynamic light scattering (DLS) to confirm vesicle particle size in the nanometre range, encapsulation efficiency testing to confirm the percentage of active material incorporated into the phospholipid vesicles, and NanoVerify — Malaysia’s nanotechnology verification programme. These are quality-control measurements, not clinical outcomes.

What standardisation markers should a Manjakani + Kacip Fatimah CoA carry?

The CoA should confirm tannic acid at 65–70% for the Manjakani (Quercus infectoria) fraction and gallic acid at 0.3–0.8% for the Kacip Fatimah (Labisia pumila) fraction, both on a 100:1 extraction ratio. Heavy-metal limits, microbial counts, moisture content and particle size should also be confirmed. For a Herbosomal® formulation, the finished-product CoA should additionally carry DLS particle-size data and encapsulation efficiency.

Which OEM formats suit a Herbosomal® Manjakani + Kacip Fatimah product?

Herbosomal® liposomal formulations require a liquid or gel phase to maintain vesicle integrity, so the suitable formats are liquid sachets, gel sachets and liquid bottles. A standard extract formulation can additionally use powder sachets, pouch beverages and chewable tablets, as the extract powder does not require a liquid phase.

What halal certification should a brand owner verify for these ingredients?

A brand owner should verify three levels: the raw-ingredient JAKIM halal certificate for both Manjakani and Kacip Fatimah extracts, the manufacturing facility’s JAKIM halal certification, and the finished-product halal status. Both ingredients appear on Bionutricia’s JAKIM halal certificates, and the manufacturing facility in Sungai Buloh operates under JAKIM halal certification.

Related Guides

• Kacip Fatimah (Labisia pumila) Extract OEM: Standardisation & Specifications
• Phytosome vs Liposomal Encapsulation: Which Technology Suits Botanicals?
• Liposomal Supplement OEM: What Brand Owners Should Know Before Choosing a Manufacturer

Article by Bionutricia R&D Team. Last updated: 30 September 2026.