Mangosteen Peel Extract (Garcinia Mangostana Extract)

Mangosteen, Garcinia mangostana L., is known as the “Queen of fruits” in Asia and can be cultivated in the tropical rainforest such as Malaysia, Indonesia, and Thailand. The purple ripe fruits consist of 6-8 seeds, and have a white and juicy pulp. Normally, people just eat the sweet pulp and throw away the purple peel.

However, studies found out that mangosteen peel is also useful, and the peel even contains more antioxidant than the pulp. Mangosteen extracts and purified constituents have been subjected to a wide array of biological tests particularly to infectious diseases, cancer chemotherapy and cancer chemoprevention, diabetes, and neurological conditions.

Pure Mangosteen Peel Garcinia mangostana Extract must have Xanthone!

Without Xanthone, its not Mangosteen Peel Garcinia mangostana!

1-2% Xanthone (Bioactive Phytochemicals)

No harm/chemicals/preservative, just harmony, manufactured naturally

Vegan
Non-GMO
No Fillers
No Flavors
No Additives
No Preservatives
No Artificial Colors
Soy and Gluten Free
Lab Tested for Authentic & Active Compound
Origin from Malaysia Borneo Forest

Reduce inflammation
Healthy weight management
Blood sugar control
Strengthen immunity system
Improve skin health

	BIONUTRICIA Garcinia mangostana Mangosteen Peel Extract	BRAND X
Certification	Registered with the Ministry of Health, Halal Tested	Not registered & certified
Raw Ingredients	Garcinia mangostana Mangosteen Peel from Malaysia	Very little / no raw ingredients; Use non-Mangosteen Peel materials
Process	Extracted through R.O. water & Ultra-sonic; Full bio-active ingredients	Grinded peel powder; Extracted through ethanol process
Active Compound	Tested with high amount of Xanthone	Not Tested
Formulation	Only Mangosteen Peel – which is proven safe and effective	Combination of other ingredients (effectiveness & safety is not proven); Added with prohibited drugs
Label	Transparent, standardized Mangosteen Peel extract with 1-2% Xanthone	Misleading claim (quantity), incorrect amount of Mangosteen Peel extract, mostly filler ingredients

Compounds isolated from the fruit peel of mangosteen contain abundant xanthones, for example: α-mangostin, β-mangostin, γ-mangostin, gartanin, 8-deoxygartanin, and mangostanol. α-mangostin represents the majority of the clinical benefits of this plant, therefore determination of the concentration of α-mangostin as a chemical marker to quality control of G. mangostana and its products is usually done and marked in labels. Nowadays, mangosteen extract is also popularly applied to cosmetic and pharmaceutical products.

Anti-tumor

In vivo & in vitro study on effect of Mangosteen peel extract on tumor
Subject	Cancerous female mice (n=30)
Duration of the study	6 weeks
Dosage	Xanthones extract (10mg/kg, 20mg/kg/day)
Groups	Negative control Treatment group
Parameters analysed	Survival rate, tumor growth, histopathologic and mechanism study
Function LG extract has both hypoglycemic and hypolipidemic effects.	Visible benefits 20 mg/kg of extract resulted in prolonged survival rates and increased inhibition of tumor growth and lymph node metastasis. The extract elevated apoptotic cell death and increased expression of active caspase-3 and -9 of cancer cells.

Anti-cancer

In vivo & in vitro study on effect of Mangosteen peel extract on colon cancer
Subject	Nude mice (n=24)
Duration of the study	20 days
Dosage	0.25% and 0.5% extract
Groups	Negative control Treatment group
Parameters analysed	Tumor size, histopathologic and mechanism study
Function α-mangostin and the G. mangostana xanthones are potential anti-colon cancer candidate.	Visible benefits The xanthone extract has cytotoxicity comparable to the drug and 2 times higher selectivity towards the colon cancer cells compared to normal cells. The extract and α-mangostin inhibited 3 key steps in tumor metastasis including the cell migration, cell invasion and clonogenicity.

Anti-inflammation

In vivo study on effect of Mangosteen peel extract on inflammation
Subject	Carrageenan-induced paw edema in mice (n=12)
Duration of the study	6 hours
Dosage	α-mangostin (20 mg/kg, p.o.)
Groups	Negative control Treatment group Positive control
Parameters analysed	Foot-pad thickness
Function α-mangostins from G. mangostana is a bioactive substance with anti-inflammatory effects.	Visible benefits α-Mangostin exhibited a potent inhibition on paw edema at 3 h.

Boost Immune System

In vivo study on effect of Mangosteen peel extract on human immune function
Subject	59 healthy human subjects (40–60 years old)
Duration of the study	30 days
Dosage	59-mL dose per day
Groups	Placebo Treatment group
Parameters analysed	Analysis of immune function Questionnaire of health status
Function Intake of an antioxidant-rich product significantly enhanced immune responses and improved overall health status.	Visible benefits The treatment group had increased peripheral T-helper cell frequency and reduced serum C-reactive protein concentration. Serum IL-1a and IL-1b concentrations in the treatment group were significantly higher than the placebo. More participants in the treatment group reported greatly improved overall health status compared with placebo.

Beauty Skin

In vivo study on effect of Mangosteen peel extract on skin
Subject	Healthy women aged 32-48 (n = 11)
Duration of the study	12 weeks
Dosage	Mangosteen peel (100 mg/day) in tablet
Groups	Treatment group
Parameters analysed	Skin AGEs by autofluorescence function Cell elasticity and moisture content
Function Intake of the supplement reduces the glycation stress and results in the improvement of skin conditions.	Visible benefits Mangosteen peel extract reduced serum pentosidine contents. It reduced advanced glycation end-products (AGEs) accumulation in the skin. It improved the elasticity and moisture content of the skin.

Bone Health

In vivo study on effect of Mangosteen peel extract on bone
Subject	Mice (n =12)
Duration of the study	7 days
Dosage	20mg/kg, 40mg/kg
Groups	Vehicle control Negative control Treatment group
Parameters analysed	Femur defect diameter by dental digital radiography
Function Application of a 40 mg/kg dose of mangosteen peel extract promotes bone fracture healing.	Visible benefits The femoral defect diameter in 40 mg/kg treated group was less than the negative control.

Standardized Pure 100:1 Garcinia mangostana Mangosteen Peel Powder Extract

Pure 100:1 Garcinia Mangostana Mangosteen Peel
1-2% Xanthone (Bio-active Phytonutrient)
Ultrasonic solvent extraction
Scientifically tested
Reduce inflammation
Healthy weight management
Blood sugar control
Strengthen immunity system
Improve skin health

Knowledge: Mangosteen Peel (Garcinia mangostana)